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Remarkable advances in the capacity to sequence genomes present tremendous opportunities that range from improving human health to understanding the biological diversity around us. The statistical and computational analysis of the voluminous sequence data, which is now being rapidly produced, is a critical step for translating advances in genomic sequencing into biologically useful information. Among the methods that facilitate this transformation are evolutionary bioinformatics analyses that are essential for inferring evolutionary histories, recognizing tracks of adaptive evolution, identifying conserved sequences, and analyzing variants that may underlie adaptations and phenotypes. Our researchers are developing state-of-the-art methods and advancing existing approaches to facilitate biological discovery.