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The application of most statistical methods developed for comparative sequence analysis requires the use of computers. Biologist-friendly computer programs are essential for the detailed analysis of molecular sequences. We realized this growing need early in the early 1990’s and developed the Molecular Evolutionary Genetics Analysis (MEGA) to facilitate the exploration and analysis of the DNA and protein sequence variation.

Currently in its seventh major release, MEGA provides facilities for assembling sequence alignments, exploring data and results interactively, inferring evolutionary trees, estimating distances and diversity, inferring ancestral sequences, computing timetrees, and testing for selection. MEGA has been used extensively in a variety of research disciplines, including AIDS/HIV research, virology, microbiology, plant biology, conservation biology, systematics, developmental evolution, population genetics, and molecular evolution.